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Nitrofurantoin low eGFR — GPhC CRA MCQ

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ModerateInfectionsNitrofurantoin low eGFRGPhC CRA

An older woman with eGFR 27 is prescribed nitrofurantoin modified-release for lower UTI. What is the most appropriate alternative?

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Correct answer: D — Query nitrofurantoin because renal function is below usual suitability

This scenario assesses Nitrofurantoin low eGFR in a UK pharmacy practice context. Nitrofurantoin requires adequate renal function to achieve urinary concentrations and avoid toxicity. The best answer is Query nitrofurantoin because renal function is below usual suitability because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF; NICE CKS