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Sildenafil nitrates — GPhC CRA MCQ

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HardDrug InteractionsSildenafil nitratesGPhC CRA

A patient using isosorbide mononitrate asks for sildenafil. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DSevere hypotension risk

This scenario assesses Sildenafil nitrates in a UK pharmacy practice context. PDE5 inhibitors potentiate nitrate vasodilation and can cause dangerous hypotension. The best answer is Severe hypotension risk because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF