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Grapefruit simvastatin — GPhC CRA MCQ

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ModerateDrug InteractionsGrapefruit simvastatinGPhC CRA

A man taking simvastatin drinks grapefruit juice every morning. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Discuss changing statin therapy if grapefruit intake will continue

This scenario assesses Grapefruit simvastatin in a UK pharmacy practice context. Grapefruit juice can increase simvastatin exposure, so ongoing intake may require a different lipid-lowering plan. The best answer is Discuss changing statin therapy if grapefruit intake will continue because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF