Lithium and ibuprofen — GPhC CRA MCQ
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Correct answer: C — Increased lithium concentration and toxicity
This scenario assesses Lithium and ibuprofen in a UK pharmacy practice context. NSAIDs can reduce renal lithium clearance and increase toxicity risk, especially with ACE inhibitors or dehydration. The best answer is Increased lithium concentration and toxicity because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.
Reference: BNF