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Clopidogrel and omeprazole — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsClopidogrel and omeprazoleGPhC CRA

A woman taking clopidogrel after stroke is prescribed omeprazole for gastroprotection because of previous peptic ulcer disease. What is the most important interaction to flag?

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Correct answer: A — Reduced clopidogrel activation with omeprazole

This scenario assesses Clopidogrel and omeprazole in a UK pharmacy practice context. Omeprazole can inhibit CYP2C19 and reduce formation of clopidogrel’s active metabolite. The best answer is Reduced clopidogrel activation with omeprazole because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF; MHRA Drug Safety Update