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Isotretinoin doxycycline — GPhC CRA MCQ

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HardDrug InteractionsIsotretinoin doxycyclineGPhC CRA

A patient on isotretinoin is prescribed doxycycline and reports headaches with previous acne therapy. What is the most important interaction to flag?

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Correct answer: A — Raised intracranial pressure risk

This scenario assesses Isotretinoin doxycycline in a UK pharmacy practice context. Isotretinoin with tetracyclines increases risk of benign intracranial hypertension. The best answer is Raised intracranial pressure risk because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF