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Metformin low eGFR acute illness — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsMetformin low eGFR acute illnessGPhC CRA

A man taking metformin has eGFR 28 after an acute dehydrating illness and asks for his usual repeat. What is the most appropriate action?

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Correct answer: B — Withhold metformin and seek urgent prescriber review

This scenario assesses Metformin low eGFR acute illness in a UK pharmacy practice context. Metformin should be stopped or reviewed at low eGFR and during acute illness because of lactic acidosis risk. The best answer is Withhold metformin and seek urgent prescriber review because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF; NICE CKS