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SSRI NSAID — GPhC CRA MCQ

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HardDrug InteractionsSSRI NSAIDGPhC CRA

A man taking fluoxetine asks to buy naproxen and has a history of dyspepsia. What is the most important interaction to flag?

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Correct answer: C — Increased gastrointestinal bleeding risk

This scenario assesses SSRI NSAID in a UK pharmacy practice context. SSRIs impair platelet function and NSAIDs increase GI bleeding risk. The best answer is Increased gastrointestinal bleeding risk because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF