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Clozapine smoking cessation — GPhC CRA MCQ

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ModerateDrug InteractionsClozapine smoking cessationGPhC CRA

A man stable on clozapine plans to stop smoking using nicotine replacement therapy. What is the most appropriate action?

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Correct answer: C — Inform the clozapine team because clozapine levels may rise

This scenario assesses Clozapine smoking cessation in a UK pharmacy practice context. Stopping tobacco smoke exposure reduces CYP1A2 induction and can increase clozapine concentrations. The best answer is Inform the clozapine team because clozapine levels may rise because it addresses the principal clinical, legal or safety issue before routine supply. The other options are less appropriate because they either miss the key risk, delay necessary review, or would not meet expected BNF, NICE, MEP, MHRA or GPhC practice standards.

Reference: BNF