skip to main content

Clopidogrel and omeprazole — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateDrug InteractionsClopidogrel and omeprazoleGPhC CRA

A patient taking clopidogrel after a stroke buys omeprazole for reflux every month. He asks for another pack. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Omeprazole can reduce activation of clopidogrel

Omeprazole inhibits CYP2C19, which contributes to clopidogrel activation. Alternatives such as lansoprazole may be preferred where a PPI is needed. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF