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Sildenafil and nitrates — GPhC CRA MCQ

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EasyDrug InteractionsSildenafil and nitratesGPhC CRA

A man prescribed isosorbide mononitrate for angina asks to buy sildenafil for erectile dysfunction. What is the most important interaction to flag?

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Correct answer: E — Severe hypotension can occur with nitrates and sildenafil

PDE5 inhibitors such as sildenafil are contraindicated with nitrates because profound hypotension can occur. The patient should be referred to the prescriber for safer management. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF