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Citalopram and QT prolongation — GPhC CRA MCQ

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ModerateDrug InteractionsCitalopram and QT prolongationGPhC CRA

A patient taking citalopram 40 mg daily is prescribed erythromycin. She has a history of prolonged QT interval. What is the most important interaction to flag?

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Correct answer: B — Additive QT prolongation and arrhythmia risk

Citalopram and erythromycin can both prolong the QT interval. Existing QT prolongation makes this combination particularly concerning, so antibiotic and antidepressant risk should be reviewed. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; MHRA Drug Safety Update