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Statin rhabdomyolysis — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyStatin rhabdomyolysisGPhC CRA

A patient taking atorvastatin and recent clarithromycin reports severe muscle pain, weakness and cola-coloured urine. What is the most appropriate action?

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Correct answer: A — Refer urgently for assessment of possible rhabdomyolysis

Severe muscle symptoms with dark urine suggest possible rhabdomyolysis, especially with an interacting macrolide. Urgent assessment is needed, including creatine kinase and renal function. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; MHRA Drug Safety Update