Statin muscle symptoms — GPhC CRA MCQ
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Correct answer: A — Stop atorvastatin throughout and restart seven days after fusidic acid ends
Systemic fusidic acid must not be combined with any statin because potentially fatal rhabdomyolysis has occurred. When systemic fusidic acid is essential, atorvastatin is stopped for the entire antibiotic course. MHRA advises waiting seven days after the final systemic fusidic-acid dose before restarting the statin to allow antibiotic clearance; changing to simvastatin does not avoid the class interaction.
Reference: MHRA systemic fusidic acid and statins: https://www.gov.uk/drug-safety-update/systemic-fusidic-acid-and-interaction-with-statins