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Clozapine neutropenia — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyClozapine neutropeniaGPhC CRA

A patient taking clozapine phones the pharmacy with fever and sore throat. He asks whether he can wait until his next routine blood test in 2 weeks. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Advise urgent contact with the clozapine monitoring service or prescriber today

Clozapine can cause neutropenia and agranulocytosis, which may present with fever or sore throat. Urgent assessment and blood testing are required. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; clozapine monitoring service guidance