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Mesalazine monitoring — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsMesalazine monitoringGPhC CRA

A patient taking clopidogrel after coronary stenting receives omeprazole for dyspepsia. Which intervention best manages the clinically relevant interaction?

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Correct answer: C — Ask the prescriber to select a less interacting proton-pump inhibitor

Omeprazole inhibits CYP2C19 and can reduce formation of clopidogrel’s active metabolite. Dose separation does not reliably avoid the interaction. If gastroprotection is required, an alternative such as lansoprazole or pantoprazole is generally selected after clinical review.

Reference: BNF: clopidogrel: https://bnf.nice.org.uk/drugs/clopidogrel/