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Donepezil bradycardia — GPhC CRA MCQ

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HardCNS TherapeuticsDonepezil bradycardiaGPhC CRA

A 79-year-old patient taking donepezil for dementia has dizziness and a pulse of 48 beats per minute. He also takes bisoprolol. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Refer urgently for review of bradycardia and medicines

Donepezil can cause bradycardia and syncope, and beta-blockers may compound this. A pulse of 48 beats per minute with dizziness warrants urgent clinical review. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; NICE CKS