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Colchicine renal impairment — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentColchicine renal impairmentGPhC CRA

A patient with eGFR 25 mL/min/1.73 m2 receives colchicine for gout. He asks if he can repeat courses frequently for flares. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Seek prescriber advice before repeat courses because renal impairment increases toxicity risk

Colchicine has a narrow therapeutic index and toxicity risk increases in renal impairment. Repeated courses or interacting medicines can cause serious harm, and diarrhoea may indicate toxicity. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF