skip to main content

Nitrofurantoin and eGFR — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateRenal and Hepatic ImpairmentNitrofurantoin and eGFRGPhC CRA

A care home resident with eGFR 22 mL/min/1.73 m2 has a repeat prescription for nitrofurantoin prophylaxis. The GP asks the pharmacist to review medicines. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Recommend review because nitrofurantoin is usually unsuitable at this renal function

Reduced renal function can reduce urinary nitrofurantoin concentrations and increase systemic toxicity risk. Long-term prophylaxis should be reviewed regularly and is often unsuitable at low eGFR. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; NICE CKS