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ACE inhibitor renal artery stenosis — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentACE inhibitor renal artery stenosisGPhC CRA

A patient newly started on lisinopril has creatinine rise by 45 percent after 10 days. He has known peripheral vascular disease. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Contact the prescriber urgently to review renal function and lisinopril

A modest creatinine rise can occur after ACE inhibitor initiation, but a large rise requires urgent review. Possible contributors include dehydration, NSAID use or renal artery stenosis, particularly in vascular disease. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; NICE CKS