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DOAC and NSAID — GPhC CRA MCQ

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ModerateDrug InteractionsDOAC and NSAIDGPhC CRA

A patient taking apixaban for atrial fibrillation asks to buy naproxen for shoulder pain. He has no gastroprotection and is 78 years old. What is the most important interaction to flag?

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Correct answer: E — Apixaban and naproxen increase bleeding risk

NSAIDs increase gastrointestinal bleeding risk and can compound anticoagulant-related bleeding. Older age further increases harm, so a safer analgesic option and referral for persistent pain should be considered. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-66