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Carbamazepine and DOAC — GPhC CRA MCQ

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HardDrug InteractionsCarbamazepine and DOACGPhC CRA

A patient taking carbamazepine for epilepsy is prescribed rivaroxaban for atrial fibrillation. The indication is stroke prevention. What is the most important interaction to flag?

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Correct answer: E — Carbamazepine may reduce rivaroxaban exposure and anticoagulant effect

Carbamazepine is a strong enzyme inducer and can reduce exposure to some DOACs. The prescriber should review anticoagulant choice because treatment failure may lead to stroke. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF