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Valproate and lamotrigine — GPhC CRA MCQ

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HardDrug InteractionsValproate and lamotrigineGPhC CRA

A patient taking sodium valproate is started on lamotrigine for seizures. The pharmacist notes the lamotrigine titration schedule appears rapid. What is the most important interaction to flag?

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Correct answer: B — Valproate increases lamotrigine exposure and rash risk

Valproate inhibits lamotrigine metabolism, increasing lamotrigine exposure and risk of serious rash. Lamotrigine requires slower titration when used with valproate. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF