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Ondansetron QT risk — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsOndansetron QT riskGPhC CRA

A patient prescribed ondansetron for nausea also takes amiodarone and has a history of prolonged QT interval. The prescription is for regular high-dose use. What is the most important interaction to flag?

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Correct answer: E — Additive QT prolongation and arrhythmia risk

Ondansetron can prolong the QT interval, and risk is higher with other QT-prolonging medicines such as amiodarone. The prescription should be queried and risk factors such as electrolytes considered. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF