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Fusidic acid and statins — GPhC CRA MCQ

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ModerateDrug InteractionsFusidic acid and statinsGPhC CRA

A patient taking atorvastatin 40 mg daily is prescribed oral fusidic acid for a skin infection. He asks whether to keep taking his statin. What is the most important interaction to flag?

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Correct answer: E — Fusidic acid with statins increases risk of serious muscle toxicity

Systemic fusidic acid with statins is associated with serious myopathy and rhabdomyolysis. Statin interruption or alternative antibiotic selection may be needed after prescriber review. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; MHRA Drug Safety Update