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Lithium and ACE inhibitor — GPhC CRA MCQ

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HardDrug InteractionsLithium and ACE inhibitorGPhC CRA

A patient taking lithium for bipolar disorder is newly prescribed lisinopril for hypertension. The GP asks what to watch for. What is the most important interaction to flag?

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Correct answer: C — ACE inhibitors can increase lithium concentration and toxicity risk

ACE inhibitors can reduce lithium clearance and increase toxicity risk. Lithium level and renal function monitoring should be considered after initiation or dose changes. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF