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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A patient taking fluoxetine asks to buy ibuprofen for period pain. She has a history of peptic ulcer disease. What is the most important interaction to flag?

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Correct answer: D — Combined SSRI and NSAID use increases gastrointestinal bleeding risk

SSRIs can increase bleeding tendency through platelet effects, and NSAIDs increase gastrointestinal bleeding risk. Previous ulcer disease increases risk further, so alternatives or gastroprotection need consideration. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF