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Amiodarone safety monitoring — GPhC CRA MCQ

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HardCardiovascular TherapeuticsAmiodarone safety monitoringGPhC CRA

A 70-year-old man has been started on amiodarone for recurrent atrial fibrillation. He asks why several baseline tests have been requested. What monitoring is required?

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Correct answer: C — Liver function, thyroid function, chest assessment and ECG monitoring

Amiodarone can cause thyroid dysfunction, hepatic injury, pulmonary toxicity, corneal deposits and cardiac conduction problems. Baseline and ongoing liver and thyroid function monitoring are important, and respiratory symptoms need prompt assessment. ECG monitoring may be required because of bradycardia and QT effects. Routine serum drug concentration monitoring is not the main safety strategy.

Reference: BNF