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Methadone and fluconazole — GPhC CRA MCQ

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HardDrug InteractionsMethadone and fluconazoleGPhC CRA

A patient on methadone maintenance treatment is prescribed fluconazole for oral candidiasis. He also takes citalopram. What is the most important interaction to flag?

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Correct answer: C — Raised risk of QT prolongation and methadone toxicity

Fluconazole can inhibit methadone metabolism and may contribute to QT prolongation. Citalopram also has QT-prolonging potential, increasing concern about arrhythmia risk. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF