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Edoxaban renal dose — GPhC CRA MCQ

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HardCardiovascular TherapeuticsEdoxaban renal doseGPhC CRA

A patient received a first inclisiran 284 mg injection on 2 January. The planned second dose on 2 April was missed, and the patient presents on 28 May, less than 3 months late. Which schedule is licensed?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Give 284 mg now and retain the original subsequent dosing dates

Inclisiran is given initially, again at 3 months and then every 6 months. When a planned dose is missed by less than 3 months, it is administered as soon as possible and the original dosing schedule is continued. A delay of more than 3 months triggers a new schedule starting from the late dose. The dose is not doubled and a missed second dose is not deliberately omitted.

Reference: Leqvio 284 mg solution for injection SmPC: https://www.medicines.org.uk/emc/product/12039/smpc