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PPI and Clostridioides risk — GPhC CRA MCQ

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HardGastro-intestinal TherapeuticsPPI and Clostridioides riskGPhC CRA

A care home resident has recurrent Clostridioides difficile infection. Her medication includes long-term lansoprazole without a clear current indication. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Ask the prescriber to review whether the PPI can be stopped

Proton pump inhibitors are associated with increased risk of enteric infections, including Clostridioides difficile. Reviewing and deprescribing unnecessary PPI therapy may reduce avoidable risk. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: BNF; NICE CKS