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Lower UTI nitrofurantoin renal function — GPhC CRA MCQ

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ModerateInfectionsLower UTI nitrofurantoin renal functionGPhC CRA

A woman is prescribed nitrofurantoin 100 mg modified-release twice daily for lower UTI. Her recent eGFR is 28 mL/min/1.73 m2. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: EQuery suitability because nitrofurantoin may be ineffective and unsafe at this renal function

Nitrofurantoin depends on renal secretion into urine and may be unsuitable in significant renal impairment. Antibiotic choice should account for renal function, pregnancy status, allergy history and local resistance guidance. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: NICE CKS; BNF