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Valproate risk management — GPhC CRA MCQ

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HardCNS TherapeuticsValproate risk managementGPhC CRA

A 23-year-old woman with epilepsy collects sodium valproate and says she is not using contraception. She is not planning pregnancy but might want children later. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: DRefer to the prescriber urgently and discuss pregnancy prevention requirements

Valproate is highly teratogenic and is subject to strict risk minimisation measures. Patients who could become pregnant need specialist review and pregnancy prevention counselling, but abrupt discontinuation can precipitate seizures. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.

Reference: MHRA Drug Safety Update; BNF