Valproate risk management — GPhC CRA MCQ
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Correct answer: D — Refer to the prescriber urgently and discuss pregnancy prevention requirements
Valproate is highly teratogenic and is subject to strict risk minimisation measures. Patients who could become pregnant need specialist review and pregnancy prevention counselling, but abrupt discontinuation can precipitate seizures. The other options either delay appropriate care, use an unsuitable medicine, or miss the main safety issue.
Reference: MHRA Drug Safety Update; BNF