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Montelukast neuropsychiatric effects — GPhC CRA MCQ

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ModerateRespiratory TherapeuticsMontelukast neuropsychiatric effectsGPhC CRA

A parent reports that her 9-year-old has become anxious and is having nightmares since starting montelukast for asthma. There is no acute wheeze today. What is the most appropriate action?

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Correct answer: A — Refer to the prescriber promptly to review montelukast

Montelukast has recognised neuropsychiatric adverse effects, including sleep disturbance, mood change and anxiety. The prescriber should review the risk-benefit balance and asthma plan. The pharmacist should not dismiss the concern or increase the dose. The inhaled corticosteroid is not the likely cause in this scenario.

Reference: MHRA Drug Safety Update; BNF