skip to main content

Kallmann syndrome — SCE Endocrinology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateReproductive EndocrinologyKallmann syndromeSCE Endocrinology

A 22-year-old man has delayed puberty and anosmia. Testosterone is low with low LH and FSH. MRI shows absent olfactory bulbs. What is the underlying pathophysiology?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Deficient GnRH neuronal migration

Kallmann syndrome results from impaired GnRH neuronal migration with anosmia. Androgen receptor resistance causes androgen insensitivity, not low gonadotrophins. Pulsatile GnRH or gonadotrophin therapy may induce fertility in selected patients.

Reference: Endocrine Society Hypogonadism Guidance