Graves' disease in pregnancy — SCE Endocrinology MCQ

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ModerateThyroidGraves' disease in pregnancySCE Endocrinology

A 29-year-old woman is 8 weeks pregnant and has recurrent Graves' disease. TSH is <0.01 mU/L and free T4 is 38 pmol/L. She has not started treatment. What is the most appropriate antithyroid drug in the first trimester?

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Correct answer: A — Propylthiouracil

Propylthiouracil is generally preferred in the first trimester because carbimazole is associated with embryopathy risk. Radioiodine is contraindicated in pregnancy. Treatment aims to control maternal thyrotoxicosis while avoiding fetal hypothyroidism.

Reference: NICE NG145; BNF