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PCOS-related infertility — SCE Endocrinology MCQ

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ModerateReproductive EndocrinologyPCOS-related infertilitySCE Endocrinology

A 31-year-old woman with PCOS wants pregnancy. She has infrequent ovulation despite weight-loss attempts. Tubal patency and semen analysis are normal. What is the most appropriate first-line ovulation induction?

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Correct answer: A — Letrozole

Letrozole is preferred first-line pharmacological ovulation induction for many women with anovulatory PCOS. Cabergoline is used for hyperprolactinaemia, not PCOS without prolactin excess. Optimising weight and metabolic risk remains important alongside fertility treatment.

Reference: International PCOS Guideline; NICE Fertility Guideline