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Obesity pharmacotherapy contraindication — SCE Endocrinology MCQ

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ModerateObesity/LipidObesity pharmacotherapy contraindicationSCE Endocrinology

A 46-year-old woman has BMI 32 kg/m2 and asks for semaglutide for weight management. She has a personal history of medullary thyroid carcinoma. What is the most appropriate prescribing decision?

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Correct answer: A — Avoid GLP-1 receptor agonist weight therapy because of contraindication concern

GLP-1 receptor agonists used for weight management carry cautions or contraindications around medullary thyroid carcinoma/MEN2 in product information. The history should trigger alternative obesity management discussion. Radioiodine does not prevent medullary thyroid cancer.

Reference: BNF; NICE NG246