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GLP-1 receptor agonist adverse effect — SCE Endocrinology MCQ

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ModerateDiabetesGLP-1 receptor agonist adverse effectSCE Endocrinology

A 41-year-old man with type 2 diabetes and BMI 29 kg/m2 develops heartburn and weight loss after starting oral semaglutide. HbA1c has improved but he now has persistent vomiting. What is the most appropriate management?

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Correct answer: C — Assess for GLP-1 receptor agonist intolerance and dehydration

Persistent vomiting on a GLP-1 receptor agonist requires assessment for intolerance, dehydration and complications. Increasing the dose or adding another GLP-1 drug would worsen adverse effects. Weight loss is expected, but persistent vomiting is not a benign therapeutic marker.

Reference: BNF; NICE NG28