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Acromegaly — SCE Endocrinology MCQ

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ModeratePituitaryAcromegalySCE Endocrinology

A 45-year-old woman with acromegaly undergoes trans-sphenoidal surgery. Three months later IGF-1 remains high and MRI shows residual cavernous sinus tumour. What is the most appropriate medical treatment?

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Correct answer: D — Somatostatin receptor ligand therapy

Persistent acromegaly after surgery is commonly treated with somatostatin receptor ligands, with other options including pegvisomant or dopamine agonist depending on response. Thyroid and adrenal replacement do not control GH excess. Cavernous sinus invasion reduces chance of complete surgical cure.

Reference: Endocrine Society Acromegaly Guideline; BNF