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Differentiated thyroid cancer — SCE Endocrinology MCQ

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ModerateThyroidDifferentiated thyroid cancerSCE Endocrinology

A 50-year-old woman has papillary thyroid carcinoma treated by total thyroidectomy and radioiodine. Six months later thyroglobulin is undetectable and neck ultrasound is clear. What is the most appropriate follow-up marker?

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Correct answer: B — Serum thyroglobulin with anti-thyroglobulin antibody status

After differentiated thyroid cancer, thyroglobulin is a key tumour marker but must be interpreted alongside anti-thyroglobulin antibodies. Calcitonin is used for medullary thyroid carcinoma. Ultrasound and risk-stratified TSH suppression also form part of follow-up.

Reference: British Thyroid Association Guidelines