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Ondansetron constipation — GPhC CRA MCQ

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HardGastrointestinal TherapeuticsOndansetron constipationGPhC CRA

A patient receiving ondansetron after chemotherapy reports colicky abdominal pain, progressive distension and no stool or flatus for 48 hours. Which response is most appropriate?

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Correct answer: B — Arrange immediate clinical assessment before starting constipation treatment

Ondansetron increases large-bowel transit time and commonly causes constipation. Colicky pain, distension and absolute constipation raise concern for subacute obstruction, so assessment takes priority over empiric laxative treatment. Once obstruction has been excluded, the antiemetic and bowel regimen can be reviewed in the oncology context.

Reference: Ondansetron Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/5216/smpc