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Methadone and benzodiazepine — GPhC CRA MCQ

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HardDrug InteractionsMethadone and benzodiazepineGPhC CRA

A patient on methadone maintenance presents a new diazepam prescription from urgent care. They seem drowsy in the pharmacy. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Additive sedation and respiratory depression risk

Opioid substitution therapy combined with benzodiazepines increases sedation and respiratory depression risk. Current drowsiness makes supply unsafe without review. In this scenario, the correct option is additive sedation and respiratory depression risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; MEP