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Clopidogrel and omeprazole — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsClopidogrel and omeprazoleGPhC CRA

A patient taking clopidogrel after a stent asks for omeprazole for dyspepsia. They have no alarm symptoms and are not taking an anticoagulant. What is the most important interaction to flag?

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Correct answer: A — Reduced clopidogrel activation with omeprazole

Omeprazole may reduce clopidogrel activation through CYP2C19 inhibition. A different acid-suppressing option should be considered if gastroprotection is required. In this scenario, the correct option is reduced clopidogrel activation with omeprazole. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions