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Sacubitril valsartan washout — GPhC CRA MCQ

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HardCardiovascular TherapeuticsSacubitril valsartan washoutGPhC CRA

A heart failure clinic prescribes sacubitril/valsartan for a patient currently taking ramipril. The prescription is presented the same day as the last ramipril dose. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Check that an ACE inhibitor washout has been completed

Sacubitril/valsartan must not be started immediately after an ACE inhibitor because of angioedema risk. A washout period is required before supply. In this scenario, the correct option is check that an ACE inhibitor washout has been completed. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF