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Nitrofurantoin renal function — GPhC CRA MCQ

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ModerateInfections and AntimicrobialsNitrofurantoin renal functionGPhC CRA

An older patient is prescribed nitrofurantoin for UTI. Their most recent eGFR on the discharge summary is 28 mL/min/1.73 m2. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Avoid and contact the prescriber before supply

Nitrofurantoin requires adequate renal function for efficacy and safety. Low eGFR makes treatment inappropriate except in limited circumstances requiring prescriber judgement. In this scenario, the correct option is avoid and contact the prescriber before supply. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; NICE CKS