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Dopamine antagonist in Parkinson's — GPhC CRA MCQ

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ModerateCNS TherapeuticsDopamine antagonist in Parkinson'sGPhC CRA

A patient with Parkinson's disease is prescribed metoclopramide for nausea. They collect co-careldopa regularly. What is the most important interaction to flag?

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Correct answer: C — Worsening parkinsonism from dopamine antagonism

Metoclopramide can worsen Parkinson's symptoms because it blocks dopamine receptors. A safer antiemetic option should be sought. In this scenario, the correct option is worsening parkinsonism from dopamine antagonism. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions