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PPI hypomagnesaemia — GPhC CRA MCQ

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HardGastrointestinal TherapeuticsPPI hypomagnesaemiaGPhC CRA

A patient on high-dose lansoprazole long term reports muscle cramps and palpitations. They also takes digoxin. What monitoring is required?

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Correct answer: E — Check magnesium and refer for clinical review

Long-term PPIs can be associated with hypomagnesaemia, which may be clinically important with digoxin. Symptoms warrant investigation. In this scenario, the correct option is check magnesium and refer for clinical review. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; MHRA Drug Safety Update