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PPI clopidogrel interaction — GPhC CRA MCQ

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ModerateGastrointestinal TherapeuticsPPI clopidogrel interactionGPhC CRA

A patient on clopidogrel asks for omeprazole after starting aspirin as well. They had indigestion previously with antiplatelets. What is the most appropriate alternative?

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Correct answer: C — Consider a PPI with less effect on clopidogrel activation

Omeprazole can reduce clopidogrel activation through CYP2C19 inhibition. A different gastroprotective option may be preferred where clinically appropriate. In this scenario, the correct option is consider a PPI with less effect on clopidogrel activation. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: BNF; Stockley's Drug Interactions