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Verapamil and simvastatin — GPhC CRA MCQ

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ModerateDrug InteractionsVerapamil and simvastatinGPhC CRA

A patient taking verapamil is prescribed simvastatin 40 mg at night. They previously tolerated simvastatin 20 mg. What is the most important interaction to flag?

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Correct answer: A — Increased simvastatin exposure and myopathy risk

Verapamil inhibits metabolism of simvastatin and can increase myopathy risk. Dose limits or alternative statin therapy should be considered. In this scenario, the correct option is increased simvastatin exposure and myopathy risk. The other options are plausible but do not address the key clinical, legal or safety issue as directly. This aligns with UK pharmacy practice guidance cited in the reference field.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-62